Buy Dutasteride (Avodart) online

Buy Avodart, Dutas (Dutasteride) 5-alpha-reductase inhibitor
Cheap qualitative Dutasteride 0.5 mg capsules or tablets online



HOW AND WHERE TO BUY DUTASTERIDE (AVODART) 0.5 MG CAPSULES OR TABLETS ONLINE:

AVODART: PHARMACODYNAMICS

Effect on 5-alpha-dihydrotestosterone and testosterone: The maximum effect of daily doses of dutasteride on the reduction of DHT is dose dependent and is observed within 1 to 2 weeks. After 1 and 2 weeks of daily dosing with dutasteride 0.5 mg, median serum DHT concentrations were reduced by 85% and 90%, respectively. In patients with BPH treated with dutasteride 0.5 mg / day for 4 years, the median decrease in serum DHT was 94% at 1 year, 93% at 2 years, and 95% at both 3 and 4 years. The median increase in serum testosterone was 19% at both 1 and 2 years, 26% at 3 years, and 22% at 4 years, but the mean and median levels remained within the physiologic range.

In patients with BPH treated with 5 mg / day of dutasteride or placebo for up to 12 weeks prior to transurethral resection of the prostate, mean DHT concentrations in prostatic tissue were significantly lower in the dutasteride group compared with placebo (784 and 5,793 pg / g, respectively, P < 0.001). Mean prostatic tissue concentrations of testosterone were significantly higher in the dutasteride group compared with placebo (2,073 and 93 pg / g, respectively, P < 0.001).

Adult males with genetically inherited type 2 5-alpha-reductase deficiency also have decreased DHT levels. These 5-alpha-reductase deficient males have a small prostate gland throughout life and do not develop BPH. Except for the associated urogenital defects present at birth, no other clinical abnormalities related to 5-alpha-reductase deficiency have been observed in these individuals.

Effects on other hormones: In healthy volunteers, 52 weeks of treatment with Avodart (Dutasteride) 0.5 mg / day (n = 26) resulted in no clinically significant change compared with placebo (n = 23) in sex hormone-binding globulin, estradiol, luteinizing hormone, follicle-stimulating hormone, thyroxine (free T4), and dehydroepiandrosterone. Statistically significant, baseline-adjusted mean increases compared with placebo were observed for total testosterone at 8 weeks (97.1 ng / dL, P < 0.003) and thyroid-stimulating hormone at 52 weeks (0.4 mcIU / mL, P < 0.05). The median percentage changes from baseline within the dutasteride group were 17.9% for testosterone at 8 weeks and 12.4% for thyroid-stimulating hormone at 52 weeks. After stopping dutasteride for 24 weeks, the mean levels of testosterone and thyroid-stimulating hormone had returned to baseline in the group of subjects with available data at the visit. In patients with BPH treated with dutasteride in a large randomized, double-blind, 387 placebo-controlled study, there was a median percent increase in luteinizing hormone of 12% at 6 months and 19% at both 12 and 24 months.

Other effects: Plasma lipid panel and bone mineral density were evaluated following 52 weeks of dutasteride 0.5 mg once daily in healthy volunteers. There was no change in bone mineral density as measured by dual energy X-Ray absorptiometry compared with either placebo or baseline. In addition, the plasma lipid profile (i.e., total cholesterol, low density lipoproteins, high density lipoproteins, and triglycerides) was unaffected by dutasteride. No clinically significant changes in adrenal hormone responses to ACTH stimulation were observed in a subset population (n = 13) of the 1-year healthy volunteer study.


Dutasteride related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Alfusin-D prescribing information - Alfuzosin; Dutasteride
  • Tablets; Oral; Alfuzosin Hydrochloride 10 mg; Dutasteride 0.5 mg
  • Cipla
  • Nisolone - Prednisolone
  • Tablets; Oral; Prednisolone 10 mg
  • Tablets; Oral; Prednisolone 5 mg
  • Psychotropics India


  • Recent posts:

  • Buy Avodart (Dutasteride) Online
  • Avodart prescribing information

    Copyright © Buy Dutasteride Online